I think this should be non-paywalled. There are too many parts and stories to summarize.
““Things changed almost completely, from knowing nothing at all and going on hearsay from Milan, Seoul and Wuhan — to saying, ‘Well, this is something we know we can do,'” Pascual said.
The World Health Organization also sounded a note of optimism on Tuesday, saying it sees “potentially positive data” in four or five coronavirus treatments and planned additional studies to be able to make recommendations. “We do have some treatments that seem to be in very early studies limiting the severity or the length of the illness,” spokeswoman Margaret Harris said.”
“Some theorize early failures of some drugs that target a hyperactive inflammatory response may be because those drugs tend to suppress just one in a broad category of cytokines, or proteins important in cell signaling. “It was like playing whack a mole,” explained the University of Michigan’s Kanthi. “You block one cytokine and then another one pops up.”
In addition, it seems a “cocktail” may have some hope because of the varied nature of the symptoms and effects of the virus.
It does seem that HCQ has lost its luster. Many doctors are hesitant to use it as adverse effects including death, have popped up.
Any case, science marches on.